Dados do Trabalho

Título

Complete pathological response after neoadjuvant therapy in HER2-positive gastric adenocarcinoma: Case report

Apresentação do Caso

HER2-positive gastric adenocarcinoma represents an aggressive subtype with specific therapeutic options. This case demonstrates the effectiveness of combined neoadjuvant therapy in achieving a complete pathological response.

We present the case of a 66-year-old patient with intestinal and diffuse gastric adenocarcinoma, HER2-positive by immunohistochemistry.
Neoadjuvant therapy was administered with FLOT chemotherapy plus trastuzumab, followed by laparoscopic radical subtotal gastrectomy with D2 lymph node dissection.

Discussão

Surgical pathology revealed the absence of viable tumor cells, indicating a complete pathological response. Intraoperatively, a mass was observed in the anthro-pylorus with a plane of marginal cleavage with the pancreatic capsule, without evidence of hepatic, peritoneal metastases or ascites. The patient was discharged on the fifth postoperative day without complications. After six months of follow-up, no relapse of the disease has been observed.

Comentários Finais

This case highlights the potential efficacy of combined neoadjuvant therapy (FLOT plus trastuzumab) in patients with HER2-positive gastric adenocarcinoma, achieving a complete pathological response and allowing a successful laparoscopic surgical approach.